Human R-Spondin 1 / RSPO1 Protein 11083-HNAS from Sino Biological, Inc.

Product Specs
ItemHuman R-Spondin 1 / RSPO1 Protein
CompanySino Biological, Inc.
Price Supplier Page View Company Product Page
Catalog Number11083-HNAS
Conjugate/TagUnconjugated
Purity≥ 95 % as determined by SDS-PAGE. ≥95% as determined by SEC-HPLC
TypeRecombinant protein
Molecular WeightThe recombinant human RSPO1 consists of 243 amino acids and has a predicted molecular mass of 26.8 kDa. As a result of glycosylation, the apparent molecular mass of it is approximately 40 and 31 kDa in SDS-PAGE under reducing conditions
SpeciesHuman
Molecule NameRSPO1
Source/Expression SystemCHO Stable Cells
NCBI Full Gene NameR-spondin 1
NCBI Gene AliasesCRISTIN3, RSPO
Activity1.Measured by its ability to induce activation of ßcatenin response in a Topflash Luciferase assay using HEK293T human embryonic kidney cells. The ED50 for this effect is typically 10-80 ng/mL in the presence of 5 ng/mL recombinant mouse Wnt3a. 2.Human intestinal cancer organoids were cultured with RSPO1(Cat#11083-HNAS), EGF(Cat#50482-MNCH), NOG(Cat#50688-M02H). (Routinely tested). Data provided by D1 Medical Technology. 3.Human colorectum organoids were cultured with RSPO1(Cat#11083-HNAS), EGF(Cat#50482-MNCH), NOG(Cat#50688-M02H). (Routinely tested). Data provided by D1 Medical Technology. 4.Human lung cancer organoids were cultured with FGF2(Cat#10014-HNAE), FGF4(Cat#16043-HNAE), FGF7(Cat#10210-H07E), EGF(Cat#50482-MNCH), FGF10(Cat#10573-HNAE), NOG(Cat#50688-M02H), RSPO1(Cat#11083-HNAS). (Routinely tested). Data provided by D1 Medical Technology. 5.Human lung organoids were cultured with FGF2(Cat#10014-HNAE), FGF4(Cat#16043-HNAE), FGF7(Cat#10210-H07E), EGF(Cat#50482-MNCH), FGF10(Cat#10573-HNAE), NOG(Cat#50688-M02H), RSPO1(Cat#11083-HNAS). (Routinely tested). Data provided by D1 Medical Technology. 6.Human cholangiocarcinomas organoids were cultured with FGF2(Cat#10014-HNAE), HGF(Cat#10463-HNAS), FGF7(Cat#10210-H07E), EGF(Cat#50482-MNCH), FGF10(Cat#10573-HNAE), NOG(Cat#50688-M02H), RSPO1(Cat#11083-HNAS). (Routinely tested). Data provided by D1 Medical Technology. 7.Human liver cancer organoids were cultured with FGF2(Cat#10014-HNAE), HGF(Cat#10463-HNAS), FGF7(Cat#10210-H07E), EGF(Cat#50482-MNCH), FGF10(Cat#10573-HNAE), TGFB1(Cat#10804-HNAC), NOG(Cat#50688-M02H), RSPO1(Cat#11083-HNAS). (Routinely tested). Data provided by D1 Medical Technology. 8.Human kidney cancer organoids were cultured with FGF2(Cat#10014-HNAE), FGF7(Cat#10210-H07E), EGF(Cat#50482-MNCH), FGF10(Cat#10573-HNAE), NOG(Cat#50688-M02H), RSPO1(Cat#11083-HNAS). (Routinely tested). Data provided by D1 Medical Technology. 9.Human kidney organoids were cultured with FGF7(Cat#10210-H07E), EGF(Cat#50482-MNCH), FGF10(Cat#10573-HNAE), NOG(Cat#50688-M02H), RSPO1(Cat#11083-HNAS), HGF(Cat#10463-HNAS), FGF4(Cat#16043-HNAE). (Routinely tested). Data provided by D1 Medical Technology. 10.Human gastric cancer organoids were cultured with EGF(Cat#50482-MNCH), FGF10(Cat#10573-HNAE), NOG(Cat#50688-M02H), RSPO1(Cat#11083-HNAS). (Routinely tested). Data provided by D1 Medical Technology. 11.Human stomach organoids organoids were cultured with EGF(Cat#50482-MNCH), FGF10(Cat#10573-HNAE), NOG(Cat#50688-M02H), RSPO1(Cat#11083-HNAS). (Routinely tested). Data provided by D1 Medical Technology. 12.Human breast cancer organoids were cultured with FGF7(Cat#10210-H07E), RSPO1(Cat#11083-HNAS), IGF1(Cat#10598-HNAE), EGF(Cat#50482-MNCH), NRG1 Beta 1(Cat#11609-H01H), NOG(Cat#50688-M02H). (Routinely tested). Data provided by D1 Medical Technology. 13.Human ovarian organoids were cultured with IGF1(Cat#10598-HNAE), NRG1 Beta 1(Cat#11609-H01H), RSPO1(Cat#11083-HNAS), EGF(Cat#50482-MNCH), NOG(Cat#50688-M02H). (Routinely tested). Data provided by D1 Medical Technology
FormatLyophilized from sterile PBS, PH 7.4

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Sino Biological, Inc.

1400 Liberty Ridge Drive

Suite 101

Wayne, PA 19087

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: http://www.sinobiological.com/

(1) Interleukin-33 Potentiates TGF-β Signaling to Regulate Intestinal Stem Cell Regeneration After Radiation InjuryCell TransplantJune 9, 2023Ruoyu Guan, Mengxue Pan, Xiaoya Xu, Lixia Du, Xinxin Rao, Guoxiang Fu, Tao Lv, Long Zhang, Yuanchuang Li, Peiyuan Tang, et al.containing Noggin (100 ng/mL, 50688-M02H; Sino Biological Inc., Beijing, China), R-spondin1 (500 ng/mL, 11083-HNAS; Sino Biological Inc., Beijing, China), and epidermal growth factor (EGF) (50 ng/mL, 50482-MNCH; Sino Biological Inc

(2) Feedback activation of EGFR/wild-type RAS signaling axis limits KRAS(G12D) inhibitor efficacy in KRAS(G12D)-mutated colorectal cancerOncogeneMay 1, 2023Feng J, Hu Z, Xia X, Liu X, Lian Z, Wang H, Wang L, Wang C, Zhang X, Pang X.Advanced DMEM/F12 medium containing 100 U/mL P/S, 10 mM HEPES, 2 mM Glutamine, 50 mg/mL R-spondin-1 (11083-HNAS, Sino Biological, Houston, USA), 100 ng/mL Noggin (50688-M02H, Sino Biological), 1 × B27 supplement

(3) Human early syncytiotrophoblasts are highly susceptible to SARS-CoV-2 infectionCell reports. MedicineDecember 20, 2022Ruan D, Ye ZW, Yuan S, Li Z, Zhang W, Ong CP, Tang K, Ka Ki Tam TT, Guo J, Xuan Y, et al.Recombinant",Sino biological,Cat: 10463-HNAS "RSPO1 Protein, Human, Recombinant",Sino biological,Cat: 11083-HNAS "DMSO, Anhydrous",Thermo Fisher Scientific,D12345 BSA solution,Sigma-Aldrich,A7979 Recombinant Human

(4) Patient-Derived Organoid Model in the Prediction of Chemotherapeutic Drug Response in Colorectal CancerACS biomaterials science & engineeringAugust 8, 2022Hao M, Cao Z, Wang Z, Xin J, Kong B, Xu J, Zhang L, Chen P.

(5) Molecular Biomarker of Drug Resistance Developed From Patient-Derived Organoids Predicts Survival of Colorectal Cancer PatientsFrontiers in OncologyMarch 29, 2022Lifeng Chen, Bo Tian, Wen Liu, Haitao Liang, Yong You, Weizhen Liu17502-048), 1× B27 supplement (Invitrogen, 17504-044), 500 ng/ml R-spondin 1 (Sino Biological Inc., 11083-HNAS), 100 ng/ml Noggin (Sino Biological Inc., 50688-M02H), 50 ng/ml epidermal growth factor (EGF) (Sino Biological Inc

(6) Bach2 Deficiency Promotes Intestinal Epithelial Regeneration by Accelerating DNA Repair in Intestinal Stem CellsStem cell reportsJanuary 12, 2021Li Y, Rao X, Tang P, Chen S, Guo Q, Fu G, Pan M, Liang L, Yao Y, Gao X, et al.50482-MNCH), 100 ng/mL Noggin (Sino Biological, 50688-M02H), and 500 ng/mL R-spondin1 (Sino Biological, 11083-HNAS). Organoids were monitored and imaged under microscopy (Zeiss, Vert.A1). The number and size of surviving

(7) Organoid modelling identifies that DACH1 functions as a tumour promoter in colorectal cancer by modulating BMP signallingEBioMedicineJune 1, 2020Hu X, Zhang L, Li Y, Ma X, Dai W, Gao X, Rao X, Fu G, Wang R, Pan M, et al.

(8) Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal CancerCell stem cellJanuary 2, 2020Yao Y, Xu X, Yang L, Zhu J, Wan J, Shen L, Xia F, Fu G, Deng Y, Pan M, et al.

(9) Inhibition of SIRT1 promotes taste bud stem cell survival and mitigates radiation-induced oral mucositis in miceAmerican journal of translational researchJanuary 1, 2019Guo Q, Chen S, Rao X, Li Y, Pan M, Fu G, Yao Y, Gao X, Tang P, Zhou Y, et al.

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Organoid Technology in Drug Discovery
March 21, 2024
High-quality products are essential to culture, manipulate, and characterize these complex multicellular model systems read more

Human R-Spondin 1 / RSPO1 Protein

Human R-Spondin 1 / RSPO1 Protein

Human R-Spondin 1 / RSPO1 Protein from Sino Biological, Inc.

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Sino Biological, Inc.

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Organoid Technology in Drug Discovery

Human R-Spondin 1 / RSPO1 Protein from Sino Biological, Inc.

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